Jonathan | Brunger

Education

2016-Present

2008 - 2015

2004

Research Interests

Establishing precisely defined control of cells' behaviors in response to multifactorial environmental inputs to direct cellular trafficking and differentiation with the aim of coordinating balanced tissue remodeling to achieve functional restoration of pathological tissues.

Awards

2017 F32 Ruth L. Kirschstein National Research Service Award (NIH)

2016 New Investigator Research Award, 62nd Annual Meeting of the Orthopaedic Research Society.

2015 Meritorious Achievement Travel Award, 18th Annual Meeting of the American Society of Gene and Cell Therapy.

2015 Student Travel Award, Biomedical Engineering Society, Cellular and Molecular Bioengineering Special Interest Group.

Publications

Adkar, S.S., Brunger J.M., Willard, V.P., Wu., C-L, Gersbach, C.A., Guilak, F. "Genome Engineering for Personalized Arthritis Therapeutics." Trends Mol Med. 2017;23(10):917-931. doi:10.1016/j.molmed.2017.08.002

Farhang, N., Brunger J.M., Stover, J.D., Thakore, P.I., Lawrence, B., Guilak, F., Gersbach, C.A., Setton, L.A., Bowles, R.D. "CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments." Tissue Eng Part A. 2017 Aug;23(15-16):738-749 doi: 10.1089/ten.TEA.2016.0441

Brunger J.M., Zutshi, A., Willard, V.P., Gersbach, C.A., Guilak, F. "Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs."" Stem Cell Reports. 2017 May; 8(5): 1202-1213.

Brunger J.M., Zutshi, A., Willard, V.P., Gersbach, C.A., Guilak, F. "CRISPR/Cas9 editing of induced pluripotent stem cells for engineering inflammation-resistant tissues." Arthritis Rheumatol. 2017 May;69(5):1111-1121

Diekman, B.O., Thakore, P.T., O’Connor S., Willard V.P., Brunger J.M., Christoforou N., Leong K.W., Gersbach C.A., Guilak F. "Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells."" Tissue Eng Part A. 2015 Apr;21(7-8):1261-74.

Glass K.A., Link J.M., Brunger J.M., Moutos F.T., Gersbach C.A., Guilak F. "Tissue-engineered cartilage with inducible and tunable immunomodulatory properties."" Biomaterials. 2014 Jul;35(22):5921-31.

Brunger J.M., Huynh N.P., Guenther C.M., Perez-Pinera P., Moutos F.T., Sanchez-Adams J., Gersbach C.A., Guilak F. "Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage." Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):E798-806.

Francisco A.T., Mancino R.J., Bowles R.D., Brunger J.M., Tainter D.M., Chen Y.T., Richardson W.J., Guilak F., Setton L.A. "Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration." Biomaterials. 2013 Oct;34(30):7381-8.

Perez-Pinera P., Ousterout D.G., Brunger J.M., Farin A.M., Glass K.A., Guilak F., Crawford G.E., Hartemink A.J., Gersbach C.A. "Synergistic and tunable human gene activation by combinations of synthetic transcription factors." Nat Methods. 2013 Mar;10(3):239-42.

Abrahamsson C.K., Yang F., Park H., Brunger J.M., Valonen P.K., Langer R., Welter J.F., Caplan A.I., Guilak F., Freed L.E. "Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds." Tissue Eng Part A. 2010 Dec;16(12):3709-18.